Cardiac contractility modulator: new hope for heart failure patients

Abstract

Cardiac contractility modulation （CCM） is a novel treatment method for patients with heart failure. It can enhance myocardial contractility by regulating the concentration of calcium ions in cardiomyocytes and modulating autonomic nerve function， thereby mitigating relevant symptoms， improving exercise tolerance， quality of life， myocardial contractility and ventricular remodeling in patients with heart failure， whereas it does not increase myocardial oxygen consumption. CCM is especially suitable for patients with a left ventricular ejection fraction of 35%-45%. Widespread application of CCM can bring new hope to patients with heart failure. In this article， the mechanism， indications， clinical efficacy and safety of CCM were reviewed， aiming to provide reference for clinicians.

Keywords

• |cardiac contractility modulation|heart failure|calcium ion|heart -assist device|cardiac resynchronization therapy