Role of non-coding RNAs in skin photoaging

Abstract

Skin photoaging, a phenomenon of premature skin aging due to prolonged exposure to ultraviolet (UV) radiation, manifests as wrinkles, loss of skin elasticity, pigmentation disorders, and age spots. Non-coding RNAs (ncRNAs), including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs), play a crucial role in regulating gene expression and the development of skin photoaging. This review summarizes the molecular mechanisms of specific ncRNAs (such as miR-34a, miR-134, miR-1246, lncRNA H19-miR-296-5p-IGF2, lncRNA PVT1-miR-551b-3p-AQP3, lncRNAMeg3-miR-93-5p-epiregulin, circ-COL3A1-859267 and circ-0011129) in skin photoaging. Additionally, the review discusses the potential application of ncRNA-based therapies in photoaging, as well as the current challenges and future research directions.

Keywords

• skin photoaging
• non-coding rna
• mirna
• lncrna
• circrna
• inflammatory response
• oxidative stress
• extracellular matrix remodeling