Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from <i>Streptomyces</i> sp. MS751

Jiaming Yu; Hui Guo; Jing Zhang; Jiansen Hu; Hongtao He; Caixia Chen; Na Yang; Fan Yang; Zexu Lin; Huanqin Dai; Liming Ouyang; Cuihua Liu; Xiaoguang Lei; Lixin Zhang; Guoliang Zhu; Fuhang Song

doi:10.3390/md22060259

Marine Drugs (Jun 2024)

Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from <i>Streptomyces</i> sp. MS751

Jiaming Yu,
Hui Guo,
Jing Zhang,
Jiansen Hu,
Hongtao He,
Caixia Chen,
Na Yang,
Fan Yang,
Zexu Lin,
Huanqin Dai,
Liming Ouyang,
Cuihua Liu,
Xiaoguang Lei,
Lixin Zhang,
Guoliang Zhu,
Fuhang Song

Affiliations

Jiaming Yu: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Hui Guo: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Jing Zhang: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Jiansen Hu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Hongtao He: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Caixia Chen: Technology Transfer Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Na Yang: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Fan Yang: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Zexu Lin: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Huanqin Dai: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Liming Ouyang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Cuihua Liu: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Xiaoguang Lei: Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Lixin Zhang: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Guoliang Zhu: State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Fuhang Song: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

DOI: https://doi.org/10.3390/md22060259
Journal volume & issue: Vol. 22, no. 6
p. 259

Abstract

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A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6), B (7), and C (8), were isolated and characterised from a strain of Streptomyces sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis. Chrysomycin F contains two diastereomers, whose structures were further elucidated by a biomimetic [2 + 2] photodimerisation of chrysomycin A. Chrysomycins B and C showed potent anti-tuberculosis activity against both wild-type Mycobacterium tuberculosis and a number of clinically isolated MDR M. tuberculosis strains.

Published in Marine Drugs

ISSN: 1660-3397 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Biology (General)
Website: http://www.mdpi.com/journal/marinedrugs

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