Chrysomycins, Anti-Tuberculosis C-Glycoside Polyketides from <i>Streptomyces</i> sp. MS751
Jiaming Yu,
Hui Guo,
Jing Zhang,
Jiansen Hu,
Hongtao He,
Caixia Chen,
Na Yang,
Fan Yang,
Zexu Lin,
Huanqin Dai,
Liming Ouyang,
Cuihua Liu,
Xiaoguang Lei,
Lixin Zhang,
Guoliang Zhu,
Fuhang Song
Affiliations
Jiaming Yu
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Hui Guo
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Jing Zhang
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Jiansen Hu
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Hongtao He
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Caixia Chen
Technology Transfer Center, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Na Yang
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Fan Yang
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Zexu Lin
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Huanqin Dai
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Liming Ouyang
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Cuihua Liu
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
Xiaoguang Lei
Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry and Molecular Engineering, and Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China
Lixin Zhang
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Guoliang Zhu
State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China
Fuhang Song
CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China
A new dimeric C-glycoside polyketide chrysomycin F (1), along with four new monomeric compounds, chrysomycins G (2), H (3), I (4), J (5), as well as three known analogues, chrysomycins A (6), B (7), and C (8), were isolated and characterised from a strain of Streptomyces sp. obtained from a sediment sample collected from the South China Sea. Their structures were determined by detailed spectroscopic analysis. Chrysomycin F contains two diastereomers, whose structures were further elucidated by a biomimetic [2 + 2] photodimerisation of chrysomycin A. Chrysomycins B and C showed potent anti-tuberculosis activity against both wild-type Mycobacterium tuberculosis and a number of clinically isolated MDR M. tuberculosis strains.
