Frontiers in Immunology (Sep 2024)
A clinical protocol for a German birth cohort study of the Maturation of Immunity Against respiratory viral Infections (MIAI)
- Carina R. Hartmann,
- Robin Khan,
- Jennifer Schöning,
- Maximilian Richter,
- Maike Willers,
- Sabine Pirr,
- Sabine Pirr,
- Julia Heckmann,
- Johannes Dirks,
- Johannes Dirks,
- Henner Morbach,
- Henner Morbach,
- Monika Konrad,
- Elena Fries,
- Magdalene Winkler,
- Johanna Büchel,
- Silvia Seidenspinner,
- Jonas Fischer,
- Claudia Vollmuth,
- Martin Meinhardt,
- Janina Marissen,
- Mirco Schmolke,
- Mirco Schmolke,
- Sibylle Haid,
- Thomas Pietschmann,
- Thomas Pietschmann,
- Thomas Pietschmann,
- Simone Backes,
- Lars Dölken,
- Lars Dölken,
- Ulrike Löber,
- Ulrike Löber,
- Ulrike Löber,
- Ulrike Löber,
- Thomas Keil,
- Thomas Keil,
- Thomas Keil,
- Peter U. Heuschmann,
- Peter U. Heuschmann,
- Peter U. Heuschmann,
- Achim Wöckel,
- Sagar,
- Thomas Ulas,
- Thomas Ulas,
- Thomas Ulas,
- Sofia K. Forslund-Startceva,
- Sofia K. Forslund-Startceva,
- Sofia K. Forslund-Startceva,
- Sofia K. Forslund-Startceva,
- Christoph Härtel,
- Dorothee Viemann,
- Dorothee Viemann,
- Dorothee Viemann,
- Dorothee Viemann
Affiliations
- Carina R. Hartmann
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Robin Khan
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Jennifer Schöning
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Maximilian Richter
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Maike Willers
- Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany
- Sabine Pirr
- Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany
- Sabine Pirr
- Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany
- Julia Heckmann
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Johannes Dirks
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Johannes Dirks
- German Center for Infection Research, Site Hamburg-Lübeck-Borstel-Riems, Hamburg, Germany
- Henner Morbach
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Henner Morbach
- Center for Primary Immunodeficiencies and Autoinflammatory Diseases (CIDA), University Hospital Würzburg, Würzburg, Germany
- Monika Konrad
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Elena Fries
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Magdalene Winkler
- Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
- Johanna Büchel
- Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
- Silvia Seidenspinner
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Jonas Fischer
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Claudia Vollmuth
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Martin Meinhardt
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Janina Marissen
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Mirco Schmolke
- Department of Microbiology and Molecular Medicine, University of Geneva, Geneva, Switzerland
- Mirco Schmolke
- Center for Inflammation Research, Faculty of Medicine, University of Geneva, Geneva, Switzerland
- Sibylle Haid
- Institute for Experimental Virology, Centre for Experimental and Clinical Infection Research (TWINCORE), a joint venture between the Helmholtz Centre for Infection Research and The Hannover Medical School, Hannover, Germany
- Thomas Pietschmann
- Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany
- Thomas Pietschmann
- Institute for Experimental Virology, Centre for Experimental and Clinical Infection Research (TWINCORE), a joint venture between the Helmholtz Centre for Infection Research and The Hannover Medical School, Hannover, Germany
- Thomas Pietschmann
- 0German Centre for Infection Research, Partner Site Braunschweig-Hannover, Braunschweig, Germany
- Simone Backes
- 1Institute for Virology and Immunobiology, University of Würzburg, Würzburg, Germany
- Lars Dölken
- Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany
- Lars Dölken
- 2Institute of Virology, Hannover Medical School, Hannover, Germany
- Ulrike Löber
- 3Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
- Ulrike Löber
- 4Experimental and Clinical Research Center, a cooperation of Charité - Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
- Ulrike Löber
- 5Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Ulrike Löber
- 6German Centre for Cardiovascular Research (DZHK), Partner site Berlin, Berlin, Germany
- Thomas Keil
- 7Institute of Social Medicine, Epidemiology and Health Economics, Charité - Universitätsmedizin Berlin, Berlin, Germany
- Thomas Keil
- 8Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany
- Thomas Keil
- 9State Institute of Health I, Bavarian Health and Food Safety Authority, Erlangen, Germany
- Peter U. Heuschmann
- 8Institute of Clinical Epidemiology and Biometry, University of Würzburg, Würzburg, Germany
- Peter U. Heuschmann
- 0Institute for Medical Data Science, University Hospital Würzburg, Würzburg, Germany
- Peter U. Heuschmann
- 1Clinical Trial Centre Würzburg, University Hospital Würzburg, Würzburg, Germany
- Achim Wöckel
- Department of Gynecology and Obstetrics, University Hospital Würzburg, Würzburg, Germany
- Sagar
- 2Department of Medicine II (Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases), Freiburg University Medical Center, University of Freiburg, Freiburg, Germany
- Thomas Ulas
- 3Systems Medicine, German Center for Neurodegenerative Diseases Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany
- Thomas Ulas
- 4PRECISE Platform for Single Cell Genomics and Epigenomics, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE) and University of Bonn, Bonn, Germany
- Thomas Ulas
- 5Genomics and Immunoregulation, Life and Medical Sciences (LIMES) Institute, University of Bonn, Bonn, Germany
- Sofia K. Forslund-Startceva
- 3Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany
- Sofia K. Forslund-Startceva
- 4Experimental and Clinical Research Center, a cooperation of Charité - Universitätsmedizin Berlin and Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
- Sofia K. Forslund-Startceva
- 5Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany
- Sofia K. Forslund-Startceva
- 6Structural and Computational Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany
- Christoph Härtel
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Dorothee Viemann
- Department of Pediatrics, University Hospital Würzburg, Würzburg, Germany
- Dorothee Viemann
- Department of Pediatric Pneumology, Allergology and Neonatology, Hannover Medical School, Hannover, Germany
- Dorothee Viemann
- Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany
- Dorothee Viemann
- 7Center for Infection Research, University Würzburg, Würzburg, Germany
- DOI
- https://doi.org/10.3389/fimmu.2024.1443665
- Journal volume & issue
-
Vol. 15
Abstract
IntroductionRespiratory viral infections (RVIs) are a major global contributor to morbidity and mortality. The susceptibility and outcome of RVIs are strongly age-dependent and show considerable inter-population differences, pointing to genetically and/or environmentally driven developmental variability. The factors determining the age-dependency and shaping the age-related changes of human anti-RVI immunity after birth are still elusive. MethodsWe are conducting a prospective birth cohort study aiming at identifying endogenous and environmental factors associated with the susceptibility to RVIs and their impact on cellular and humoral immune responses against the influenza A virus (IAV), respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The MIAI birth cohort enrolls healthy, full-term neonates born at the University Hospital Würzburg, Germany, with follow-up at four defined time-points during the first year of life. At each study visit, clinical metadata including diet, lifestyle, sociodemographic information, and physical examinations, are collected along with extensive biomaterial sampling. Biomaterials are used to generate comprehensive, integrated multi-omics datasets including transcriptomic, epigenomic, proteomic, metabolomic and microbiomic methods. DiscussionThe results are expected to capture a holistic picture of the variability of immune trajectories with a focus on cellular and humoral key players involved in the defense of RVIs and the impact of host and environmental factors thereon. Thereby, MIAI aims at providing insights that allow unraveling molecular mechanisms that can be targeted to promote the development of competent anti-RVI immunity in early life and prevent severe RVIs.Clinical trial registrationhttps://drks.de/search/de/trial/, identifier DRKS00034278.
Keywords
