Effect of Gynura procumbens leaf extract with biological nanoparticles on streptozotocin-induced hyperglycemia in a rat model

Abstract

Herbal medicines, a popular choice for treatments, are effective against diabetes when used with nanoparticles. Thus, this study investigates the effects of Gynura procumbens ethanolic extract with chitosan nanoparticles on streptozotocin-induced hyperglycemia in rat model. Twenty-eight days old 16 male rats were randomly divided into 4 groups such as T0 = control (normal), T1 = streptozotocin-induced diabetes, T2 = streptozotocin-induced diabetes treated with ethanolic extract of Gynura Procumbens (150 mg/kg body weight), and T3= streptozotocin induced diabetes treated with ethanolic extract of Gynura Procumbens (150 mg/kg) and chitosan nanoparticles (25 mg/kg). Blood glucose levels were significantly higher in the diabetic group T1 (26.27±1.76) compared to treatment T2 (18.32±.715) and T3 (15.45±1.33) groups. The body weight of T1 (115.75±0.08c) significantly decreased compared to control T0 (216.25±4.27) on the 21st day. Interestingly, there was significant (p [ J Adv Biotechnol Exp Ther 2024; 7(1.000): 255-265]

Keywords

• gynura procumbens
• nanoparticles
• streptozotocin
• chitosan
• diabetics
• blood glucose
• insulin