ACS Central Science (Apr 2023)
Development of a Manufacturing Process toward the Convergent Synthesis of the COVID-19 Antiviral Ensitrelvir
- Takahiro Kawajiri,
- Akihito Kijima,
- Atsuhiro Iimuro,
- Eisaku Ohashi,
- Katsuya Yamakawa,
- Kazushi Agura,
- Kengo Masuda,
- Kensuke Kouki,
- Koji Kasamatsu,
- Shuichi Yanagisawa,
- Sho Nakashima,
- Setsuya Shibahara,
- Takashi Toyota,
- Takafumi Higuchi,
- Takahiro Suto,
- Tadashi Oohara,
- Toshikatsu Maki,
- Naoto Sahara,
- Nobuaki Fukui,
- Hisayuki Wakamori,
- Hidaka Ikemoto,
- Hiroaki Murakami,
- Hiroyasu Ando,
- Masahiro Hosoya,
- Mizuki Sato,
- Yusuke Suzuki,
- Yuta Nakagawa,
- Yuto Unoh,
- Yoichi Hirano,
- Yoshitomo Nagasawa,
- Satoshi Goda,
- Takafumi Ohara,
- Takayuki Tsuritani
Affiliations
- Takahiro Kawajiri
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Akihito Kijima
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Atsuhiro Iimuro
- Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan
- Eisaku Ohashi
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Katsuya Yamakawa
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Kazushi Agura
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Kengo Masuda
- Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan
- Kensuke Kouki
- Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan
- Koji Kasamatsu
- Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan
- Shuichi Yanagisawa
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Sho Nakashima
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Setsuya Shibahara
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Takashi Toyota
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Takafumi Higuchi
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Takahiro Suto
- Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan
- Tadashi Oohara
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Toshikatsu Maki
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Naoto Sahara
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Nobuaki Fukui
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Hisayuki Wakamori
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Hidaka Ikemoto
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Hiroaki Murakami
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Hiroyasu Ando
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Masahiro Hosoya
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Mizuki Sato
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Yusuke Suzuki
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Yuta Nakagawa
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Yuto Unoh
- Laboratory for Medicinal Chemistry Research, Research Division, Shionogi & Co., Ltd., Toyonaka, Osaka, Japan
- Yoichi Hirano
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Yoshitomo Nagasawa
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Satoshi Goda
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Takafumi Ohara
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- Takayuki Tsuritani
- API R&D Laboratory, Research Division, Shionogi & Co., Ltd., Amagasaki, Hyogo, Japan
- DOI
- https://doi.org/10.1021/acscentsci.2c01203
- Journal volume & issue
-
Vol. 9,
no. 4
pp. 836 – 843
Abstract
No abstracts available.