β subunits of GABAA receptors form proton-gated chloride channels: Insights into the molecular basis

Affiliations

Aleksandra Garifulina: Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna
Theres Friesacher: Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna
Marco Stadler: Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna
Eva-Maria Zangerl-Plessl: Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna
Margot Ernst: Department of Pathobiology of the Nervous System, Medical University of Vienna
Anna Stary-Weinzinger: Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna
Anita Willam: Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna
Steffen Hering: Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of Vienna

Abstract

Beta subunits of GABAA receptors are unexpectedly shown to form homomeric proton gated ion channels attributable to a single histidine residue.