Frontiers in Cardiovascular Medicine (Sep 2021)
Relationship Between Immunoinflammation and Coronary Physiology Evaluated by Quantitative Flow Ratio in Patients With Coronary Artery Disease
- Chengzhe Liu,
- Chengzhe Liu,
- Chengzhe Liu,
- Chengzhe Liu,
- Zhiyao Yu,
- Zhiyao Yu,
- Zhiyao Yu,
- Zhiyao Yu,
- Huaqiang Chen,
- Huaqiang Chen,
- Huaqiang Chen,
- Huaqiang Chen,
- Jun Wang,
- Jun Wang,
- Jun Wang,
- Jun Wang,
- Wei Liu,
- Wei Liu,
- Wei Liu,
- Wei Liu,
- Liping Zhou,
- Liping Zhou,
- Liping Zhou,
- Liping Zhou,
- Yueyi Wang,
- Yueyi Wang,
- Yueyi Wang,
- Yueyi Wang,
- Hu Chen,
- Hu Chen,
- Hu Chen,
- Hu Chen,
- Huixin Zhou,
- Huixin Zhou,
- Huixin Zhou,
- Huixin Zhou,
- Zhihao Liu,
- Zhihao Liu,
- Zhihao Liu,
- Zhihao Liu,
- Jiapeng Han,
- Jiapeng Han,
- Jiapeng Han,
- Jiapeng Han,
- Hong Jiang,
- Hong Jiang,
- Hong Jiang,
- Hong Jiang,
- Lilei Yu,
- Lilei Yu,
- Lilei Yu,
- Lilei Yu
Affiliations
- Chengzhe Liu
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Chengzhe Liu
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Chengzhe Liu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Chengzhe Liu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Zhiyao Yu
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Zhiyao Yu
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Zhiyao Yu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Zhiyao Yu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Huaqiang Chen
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Huaqiang Chen
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Huaqiang Chen
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Huaqiang Chen
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Jun Wang
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Jun Wang
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Jun Wang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Jun Wang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Wei Liu
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Wei Liu
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Wei Liu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Wei Liu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Liping Zhou
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Liping Zhou
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Liping Zhou
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Liping Zhou
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Yueyi Wang
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Yueyi Wang
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Yueyi Wang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Yueyi Wang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Hu Chen
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Hu Chen
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Hu Chen
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Hu Chen
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Huixin Zhou
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Huixin Zhou
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Huixin Zhou
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Huixin Zhou
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Zhihao Liu
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Zhihao Liu
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Zhihao Liu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Zhihao Liu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Jiapeng Han
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Jiapeng Han
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Jiapeng Han
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Jiapeng Han
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Hong Jiang
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Hong Jiang
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Hong Jiang
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Hong Jiang
- Hubei Key Laboratory of Cardiology, Wuhan, China
- Lilei Yu
- Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China
- Lilei Yu
- Cardiac Autonomic Nervous System Research Center of Wuhan University, Wuhan, China
- Lilei Yu
- Cardiovascular Research Institute, Wuhan University, Wuhan, China
- Lilei Yu
- Hubei Key Laboratory of Cardiology, Wuhan, China
- DOI
- https://doi.org/10.3389/fcvm.2021.714276
- Journal volume & issue
-
Vol. 8
Abstract
Background: The association between coronary physiology and immunoinflammation has not been investigated. We performed a retrospective study using quantitative flow ratio (QFR) to evaluate the interaction between immunoinflammatory biomarkers and coronary physiology.Methods: A total of 172 patients with CAD who underwent coronary arteriography (CAG) and QFR were continuously enrolled from May 2020 to February 2021. As a quantitative indicator of coronary physiology, QFR can reflect the functional severity of coronary artery stenosis. The target vessel measured by QFR was defined as that with the most severe lesions. Significant coronary anatomical stenosis was defined as 70% stenosis in the target vessel.Results: Compared with the QFR > 0.8 group, interleukin (IL)-6, IL-10, tumor necrosis factor (TNF)-α, and interferon (IFN)-γ were increased and CD3+ and CD4+ T lymphocyte counts were decreased in the QFR ≤ 0.8 group. In addition, patients with DS ≤ 70% had higher IL-6, IL-10, and TNF-α levels and decreased CD3+ and CD4+ T lymphocyte counts than those with DS > 70%. Logistic regression analysis indicated IL-6 to be an independent predictor of significant coronary functional and anatomic stenosis (odds ratio, 1.125; 95% CI, 1.059–1.196; P < 0.001). Receiver operating characteristic (ROC) analyses showed that IL-6 > 6.36 was predictive of QFR ≤ 0.8 of the target vessel. The combination of IL-6, IL-10 and CD4 improved the value for predicting QFR ≤ 0.8 of the target vessel (AUC, 0.737; 95% CI, 0.661–0.810).Conclusion: Among immunoinflammatory biomarkers, IL-6 was independently associated with a higher risk of QFR ≤ 0.8 of the target vessel. The combination of immunoinflammatory biomarkers was highly predictive of significant coronary functional and anatomic stenosis.
Keywords