Nature Communications (Dec 2022)

Myeloid cells promote interferon signaling-associated deterioration of the hematopoietic system

  • Jacqueline Feyen,
  • Zhen Ping,
  • Lanpeng Chen,
  • Claire van Dijk,
  • Tim V. D. van Tienhoven,
  • Paulina M. H. van Strien,
  • Remco M. Hoogenboezem,
  • Michiel J. W. Wevers,
  • Mathijs A. Sanders,
  • Ivo P. Touw,
  • Marc H. G. P. Raaijmakers

DOI
https://doi.org/10.1038/s41467-022-35318-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

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Innate and adaptive immune cells function in the homeostasis of haematopoietic stem cells (HSC). Here the authors show that myeloid cells are able to reduce the function of HSCs via interferon signaling through a neutrophil-NK cell dependent process.