The Particle Design of Cellulose and the Other Excipients for a Directly Compressible Filler-Binder

Abstract

Cellulose and saccharide are commonly used filler-binder. This summary refers to the technology for high performance filler-binder of direct compression, using these two materials. In case of saccharide filler-binder, spray dry technology and size controlling of primary particle were the key technology. In case of cellulose filler-binder, two different approaches were made. One was co-processing approach and the other was particle shape controlling approach. Some applications using high performance filler-binder were also introduced.

Keywords

• filler-binder
• direct compression
• microcrystalline cellulose
• compactibility
• lactose
• high performance