Burden of resistant infections caused by S. aureus, E. coli, K. pneumoniae in Russian Federation

Abstract

The burden of bacterial resistance was assessed for the first time in Russia. The analysis was based on the results of bacteriological studies in multi-field hospitals provided by the St. Petersburg Medical Information and analytical Center. The number of patients with infections caused by strains of methicillin-resistant S. aureus (MRSA); K. pneumoniae, are not sensitive to 3rd generation cephalosporins and carbapenems; E. coli, are not sensitive to 3rd generation cephalosporins was calculated on the basis of the obtained data. The data are extrapolated to all multi-profile hospitals of the Russian Federation with regard to known levels of resistance. The total cost of treatment of patients with infections caused by three pathogens in multi-field hospitals in St. Petersburg for the year amounted to 250 887 292 rubles, in Russia – 12 413 309 939 rubles. The main costs are associated with antimicrobial therapy (90% in St. Petersburg, 88 – in Russia). The costs associated with additional beds, temporary disability, epidemiological control measures are 10% and 12%, respectively. Mathematical modeling has shown that these costs can increase by at least 10% due to the death of patients of working age.

Keywords

• bacterial resistance
• disease burden
• clinical and economic analysis