Ductus Venosus Doppler S/D Value Adjusted Alfa Fetoprotein Levels to Decrease False Positive Rates

Abstract

OBJECTIVE: Fetal liver is mostly perfused by umbilical vein via ductus venosus and AFP is synthesized and secreted from fetal liver. In this study we tried to determine the effect of ductus venosus and umbilical blood flow on serum AFP levels STUDY DESIGN: Sixty women with 16-20 weeks of gestation were enrolled for the study. Subjects were divided into two: AFP levels lower (n=46) and higher than 2 MomS MoMs (n=14). All participants underwent serum AFP, ductus venosus and umbilical artery Doppler Doppler S/D screening. Effect of ductus venosus and umbilical artery blood flow on serum AFP levels were analyzed. RESULTS: Ductus venosus (AUC=0.945, P2 MoM became 1.98 MoM after adjustment. CONCLUSION: Our study revealed that Ductus venosus and umbilical artery S/D value adjusted serum AFP levels may have lower false positive rates.

Keywords

• Ductus venosus doppler, Alfa fetoprotein, Second trimester screening