A mid-infrared lab-on-a-chip for dynamic reaction monitoring

Borislav Hinkov; Florian Pilat; Laurin Lux; Patricia L. Souza; Mauro David; Andreas Schwaighofer; Daniela Ristanić; Benedikt Schwarz; Hermann Detz; Aaron M. Andrews; Bernhard Lendl; Gottfried Strasser

doi:10.1038/s41467-022-32417-7

Nature Communications (Aug 2022)

A mid-infrared lab-on-a-chip for dynamic reaction monitoring

Borislav Hinkov,
Florian Pilat,
Laurin Lux,
Patricia L. Souza,
Mauro David,
Andreas Schwaighofer,
Daniela Ristanić,
Benedikt Schwarz,
Hermann Detz,
Aaron M. Andrews,
Bernhard Lendl,
Gottfried Strasser

Affiliations

Borislav Hinkov: Institute of Solid State Electronics & Center for Micro- and Nanostructures, TU Wien
Florian Pilat: Institute of Solid State Electronics & Center for Micro- and Nanostructures, TU Wien
Laurin Lux: Institute of Chemical Technologies and Analytics, TU Wien
Patricia L. Souza: Institute of Solid State Electronics & Center for Micro- and Nanostructures, TU Wien
Mauro David: Institute of Solid State Electronics & Center for Micro- and Nanostructures, TU Wien
Andreas Schwaighofer: Institute of Chemical Technologies and Analytics, TU Wien
Daniela Ristanić: Institute of Solid State Electronics & Center for Micro- and Nanostructures, TU Wien
Benedikt Schwarz: Institute of Solid State Electronics & Center for Micro- and Nanostructures, TU Wien
Hermann Detz: Institute of Solid State Electronics & Center for Micro- and Nanostructures, TU Wien
Aaron M. Andrews: Institute of Solid State Electronics & Center for Micro- and Nanostructures, TU Wien
Bernhard Lendl: Institute of Chemical Technologies and Analytics, TU Wien
Gottfried Strasser: Institute of Solid State Electronics & Center for Micro- and Nanostructures, TU Wien

DOI: https://doi.org/10.1038/s41467-022-32417-7
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

Rapid investigation of chemical reactions is a challenge in bio-medical analysis. Here, the authors demonstrate sensitive in-situ real-time reaction-monitoring of conformational changes in protein solution, based on a fingertip-sized mid-IR lab-on-a-chip.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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