Amplification of USP13 drives ovarian cancer metabolism

Cecil Han; Lifeng Yang; Hyun Ho Choi; Joelle Baddour; Abhinav Achreja; Yunhua Liu; Yujing Li; Jiada Li; Guohui Wan; Cheng Huang; Guang Ji; Xinna Zhang; Deepak Nagrath; Xiongbin Lu

doi:10.1038/ncomms13525

Nature Communications (Nov 2016)

Amplification of USP13 drives ovarian cancer metabolism

Cecil Han,
Lifeng Yang,
Hyun Ho Choi,
Joelle Baddour,
Abhinav Achreja,
Yunhua Liu,
Yujing Li,
Jiada Li,
Guohui Wan,
Cheng Huang,
Guang Ji,
Xinna Zhang,
Deepak Nagrath,
Xiongbin Lu

Affiliations

Cecil Han: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
Lifeng Yang: Department of Chemical and Biomolecular Engineering, Rice University
Hyun Ho Choi: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
Joelle Baddour: Department of Chemical and Biomolecular Engineering, Rice University
Abhinav Achreja: Department of Chemical and Biomolecular Engineering, Rice University
Yunhua Liu: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
Yujing Li: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
Jiada Li: The State Key Laboratory of Medical Genetics and School of Life Sciences, Central South University
Guohui Wan: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center
Cheng Huang: Drug Discovery Laboratory, School of Pharmacy, Shanghai University of Traditional Chinese Medicine
Guang Ji: Institute of Digestive Diseases, Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Xinna Zhang: Department of Gynaecologic Oncology and Reproductive Medicine, The University of Texas MD Anderson Cancer Center
Deepak Nagrath: Department of Chemical and Biomolecular Engineering, Rice University
Xiongbin Lu: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center

DOI: https://doi.org/10.1038/ncomms13525
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 16

Abstract

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Cancer cells need to reprogramme their metabolism to allow rapid cell proliferation. Here, the authors show that USP13is amplified in ovarian cancer and its protein product, a deubiquitinase, drives tumour progression by rewiring the metabolism of cancer cells by stabilising two critical metabolic enzymes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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