Nature Communications (Oct 2018)

Intestinal microbiome adjusts the innate immune setpoint during colonization through negative regulation of MyD88

  • Bjørn E. V. Koch,
  • Shuxin Yang,
  • Gerda Lamers,
  • Jens Stougaard,
  • Herman P. Spaink

DOI
https://doi.org/10.1038/s41467-018-06658-4
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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It remains unclear how microbial sensing during early-life colonization results in immune homeostasis rather than acute inflammation. Here the authors show that zebrafish larvae colonization suppresses intestinal MyD88, accounting for a considerable proportion of microbiota-induced alterations in immune setpoint.