Chinese Journal of Contemporary Neurology and Neurosurgery (Jun 2023)
Advance on mechanism of type 2 diabetes mellitus increasing the risk of Parkinson's disease
Abstract
Type 2 diabetes mellitus (T2DM) is closely related to the occurrence and progress of Parkinson's disease (PD), in which neurotoxicity caused by hyperglycemia and cerebral insulin resistance may play important roles, and the specific mechanism is not certain. Chronic hyperglycemia may lead to the injury of substantia nigra dopaminergic neuron by promoting oxidative stress, neuroinflammation, the formation of advanced glycation end products and endogenous neurotoxin. Moreover, insulin resistance may be involved in several pathways. This article mainly reviews the mechanism of T2DM increasing the risk of PD and provides guidance for the prevention and treatment of PD in patients with T2DM.
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