Nature Communications (Feb 2020)
REEP5 depletion causes sarco-endoplasmic reticulum vacuolization and cardiac functional defects
- Shin-Haw Lee,
- Sina Hadipour-Lakmehsari,
- Harsha R. Murthy,
- Natalie Gibb,
- Tetsuaki Miyake,
- Allen C. T. Teng,
- Jake Cosme,
- Jessica C. Yu,
- Mark Moon,
- SangHyun Lim,
- Victoria Wong,
- Peter Liu,
- Filio Billia,
- Rodrigo Fernandez-Gonzalez,
- Igor Stagljar,
- Parveen Sharma,
- Thomas Kislinger,
- Ian C. Scott,
- Anthony O. Gramolini
Affiliations
- Shin-Haw Lee
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- Sina Hadipour-Lakmehsari
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- Harsha R. Murthy
- Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
- Natalie Gibb
- Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
- Tetsuaki Miyake
- Department of Physiology, Faculty of Medicine, University of Toronto
- Allen C. T. Teng
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- Jake Cosme
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- Jessica C. Yu
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- Mark Moon
- Department of Physiology, Faculty of Medicine, University of Toronto
- SangHyun Lim
- Donnelly Centre, University of Toronto
- Victoria Wong
- Donnelly Centre, University of Toronto
- Peter Liu
- Ottawa Heart Institute
- Filio Billia
- Toronto General Research Institute, University Health Network
- Rodrigo Fernandez-Gonzalez
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- Igor Stagljar
- Donnelly Centre, University of Toronto
- Parveen Sharma
- Department of Physiology, Faculty of Medicine, University of Toronto
- Thomas Kislinger
- Department of Medical Biophysics, University of Toronto
- Ian C. Scott
- Program in Developmental and Stem Cell Biology, The Hospital for Sick Children
- Anthony O. Gramolini
- Translational Biology and Engineering Program, Ted Rogers Centre for Heart Research
- DOI
- https://doi.org/10.1038/s41467-019-14143-9
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
The sarcoplasmic (SR) and endoplasmic reticulum (ER) are involved in heart development but how this arises is unclear. Here, the authors show that loss of a SR/ER protein REEP5 causes membrane destabilization and decreased cardiac myocyte contractility, with cardiac dysfunction in mutant mouse and zebrafish models.
