Basosquamous Cell Carcinoma of the Nipple-Areola Complex—Report of a Case
Gabriele Raimondo,
Gaetano Gallo,
Giuliano D’Onghia,
Giovanni Gabriele,
Luciano Izzo,
Andrea Polistena,
Luca Esposito,
Paola Giancontieri,
Leonardo Macci,
Vito D’Andrea,
Enrico Fiori,
Luigi Basso
Affiliations
Gabriele Raimondo
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Gaetano Gallo
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Giuliano D’Onghia
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Giovanni Gabriele
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Luciano Izzo
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Andrea Polistena
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Luca Esposito
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Paola Giancontieri
Department of Radiological, Oncological and Anatomo-Pathological Sciences, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Rome, Italy
Leonardo Macci
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Vito D’Andrea
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Enrico Fiori
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Luigi Basso
Department of Surgery, Policlinico “Umberto I”, “Sapienza” University of Rome, Viale del Policlinico 155, 00161 Roma, Italy
Basosquamous cell carcinoma (BSCC) is a rare malignancy usually arising on sun-exposed areas of the skin. BSCC is described as a rare variant of Basal cell carcinoma (BCC) which shows clinical and microscopic features of both BCC and of Squamous cell carcinoma (SCC). We report the case of a 70-year-old male with a cutaneous lesion of the nipple-areola complex (NAC); to the best of our knowledge, this is the first ever reported patient with BSCC in this area. The lesion had a fast growth, but, due to the COVID19 crisis, the patient only came to our observation one year after onset of this condition. Physical examination showed a bleeding red ulcerated lesion that involved the NAC, measuring 27 mm × 20 mm. Biopsy showed a BSCC. Pre-operative breast ultrasound scan, mammogram and MRI were all performed before surgery, which consisted of simple mastectomy and sentinel lymph-node biopsy. The patient was discharged home on the 4th post-operative day, and at 18-month follow-up there are no signs or clinical evidence of local recurrence or metastases. Diagnosis of BSCC of the nipple-areola complex requires high index of suspicion and a thorough differential diagnosis, management, and suitable radical treatment due to well described high rates of recurrence and of metastases. Differential diagnosis with similar lesions (e.g., Paget’s disease, Bowen’s disease, BCC, and SCC) should also be taken into account.
