Polydopamine-Modified functional materials promote bone regeneration

Abstract

With the increasing incidence of bone defects in clinical practice, the demand for bone grafts or substitutes has become more urgent. Polydopamine (PDA)-coated bone tissue engineering materials offer a promising alternative in such cases. PDA coating is characterized by a solid coating formed by polymerization of dopamine under alkaline and oxygen-containing conditions, which can provide implants good hydrophilicity through the active functional groups contained in the structure. More importantly, the strong adhesion of the coating can provide an anchor between bone implant materials and drugs to achieve functional modification of the implant surface to enhance bone regeneration. In this review, the different effects of dopamine derivatives and their polymerization in current research were summarized. The mechanisms underlying the effects of PDA in promoting bone regeneration have also discussed in detail, providing a theoretical basis for the clinical application of PDA. Finally, a series of PDA-coated materials for the promotion of bone repair have been summarized and discussed. This review provides cutting-edge design ideas for PDA-based biomaterials and highlights promising treatment strategies for bone defects.

Keywords

• Bone defect
• Polydopamine
• Biomaterial
• Bone regeneration