Nature Communications (Oct 2016)
Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets
- Ying-Bei Chen,
- Jianing Xu,
- Anders Jacobsen Skanderup,
- Yiyu Dong,
- A. Rose Brannon,
- Lu Wang,
- Helen H. Won,
- Patricia I. Wang,
- Gouri J. Nanjangud,
- Achim A. Jungbluth,
- Wei Li,
- Virginia Ojeda,
- A. Ari Hakimi,
- Martin H. Voss,
- Nikolaus Schultz,
- Robert J. Motzer,
- Paul Russo,
- Emily H. Cheng,
- Filippo G. Giancotti,
- William Lee,
- Michael F. Berger,
- Satish K. Tickoo,
- Victor E. Reuter,
- James J. Hsieh
Affiliations
- Ying-Bei Chen
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Jianing Xu
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Anders Jacobsen Skanderup
- Computational Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center
- Yiyu Dong
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- A. Rose Brannon
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Lu Wang
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Helen H. Won
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Patricia I. Wang
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- Gouri J. Nanjangud
- Molecular Cytogenetics Laboratory, Memorial Sloan Kettering Cancer Center
- Achim A. Jungbluth
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Wei Li
- Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center
- Virginia Ojeda
- Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center
- A. Ari Hakimi
- Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center
- Martin H. Voss
- Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center
- Nikolaus Schultz
- Computational Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center
- Robert J. Motzer
- Department of Medicine, Genitourinary Oncology Service, Memorial Sloan Kettering Cancer Center
- Paul Russo
- Department of Surgery, Urology Service, Memorial Sloan Kettering Cancer Center
- Emily H. Cheng
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Filippo G. Giancotti
- Cell Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center
- William Lee
- Computational Biology Program, Sloan Kettering Institute for Cancer Research, Memorial Sloan Kettering Cancer Center
- Michael F. Berger
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Satish K. Tickoo
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- Victor E. Reuter
- Department of Pathology, Memorial Sloan Kettering Cancer Center
- James J. Hsieh
- Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center
- DOI
- https://doi.org/10.1038/ncomms13131
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 10
Abstract
A subset of renal cell carcinomas have uncertain histology and are aggressive in nature. Here, the authors examine this group of unclassified renal cancers using genomics techniques and identify further subclasses of the tumours that have differing prognoses.
