Nature Communications (Mar 2019)
DNA damage-induced PARP1 activation confers cardiomyocyte dysfunction through NAD+ depletion in experimental atrial fibrillation
- Deli Zhang,
- Xu Hu,
- Jin Li,
- Jia Liu,
- Luciënne Baks-te Bulte,
- Marit Wiersma,
- Noor-ul-Ann Malik,
- Denise M. S. van Marion,
- Marziyeh Tolouee,
- Femke Hoogstra-Berends,
- Eva A. H. Lanters,
- Arie M. van Roon,
- Antoine A. F. de Vries,
- Daniël A. Pijnappels,
- Natasja M. S. de Groot,
- Robert H. Henning,
- Bianca J. J. M. Brundel
Affiliations
- Deli Zhang
- Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences
- Xu Hu
- Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences
- Jin Li
- Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences
- Jia Liu
- Department of Cardiology, Laboratory of Experimental Cardiology, Leiden University Medical Center
- Luciënne Baks-te Bulte
- Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences
- Marit Wiersma
- Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences
- Noor-ul-Ann Malik
- Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences
- Denise M. S. van Marion
- Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences
- Marziyeh Tolouee
- Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen
- Femke Hoogstra-Berends
- Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen
- Eva A. H. Lanters
- Department of Cardiology, Erasmus Medical Center
- Arie M. van Roon
- Department of Internal Medicine, Division of Vascular Medicine, University of Groningen, University Medical Center Groningen
- Antoine A. F. de Vries
- Department of Cardiology, Laboratory of Experimental Cardiology, Leiden University Medical Center
- Daniël A. Pijnappels
- Department of Cardiology, Laboratory of Experimental Cardiology, Leiden University Medical Center
- Natasja M. S. de Groot
- Department of Cardiology, Erasmus Medical Center
- Robert H. Henning
- Department of Clinical Pharmacy and Pharmacology, University Medical Centre Groningen, University of Groningen
- Bianca J. J. M. Brundel
- Department of Physiology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam Cardiovascular Sciences
- DOI
- https://doi.org/10.1038/s41467-019-09014-2
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 17
Abstract
Atrial fibrillation (AF) is accompanied by a detrimental loss of functional cardiomyocytes. Here, Zhang et al. show that AF-induced cardiomyocyte dysfunction is a consequence of DNA damage-mediated PARP1 activation, which leads to depletion of NAD+ and further oxidative stress and DNA damage, and identify PARP1 inhibition as a potential therapeutic strategy in the treatment of AF.
