Predictive value of early second trimester maternal serum cyclophilin A concentrations in women complicated with preeclampsia: a preliminary case–control study

Abstract

Objective To investigate cyclophilin A in early second trimester of pregnancy before the onset of preeclampsia. Methods In this prospective case-control study, 51 pregnant women whose serum were collected and stored and who developed preeclampsia in later follow-up and 41 pregnant women as control group were included. Results Maternal serum cyclophilin A levels in the study group who developed preeclampsia in later follow-up were significantly higher than those of normal healthy pregnant women. Conclusion Cyclophilin A may be a valuable predictor for pregnant women who subsequently develop preeclampsia in their pregnancies.

Keywords

• pregnancy
• gestational hypertension
• preeclampsia
• cyclophilin a
• predictive models