Российский журнал гастроэнтерологии, гепатологии, колопроктологии (Feb 2025)
Diagnosis and Treatment of Patients with Autoimmune Hepatitis (Experts’ Agreement)
- Yu. G. Sandler,
- E. V. Vinnitskaya,
- K. L. Raikhelson,
- K. V. Ivashkin,
- S. N. Batskikh,
- E. N. Aleksandrova,
- D. T. Abdurakhmanov,
- D. I. Abdulganieva,
- I. G. Bakulin,
- A. O. Bueverov,
- S. L. Vorobyev,
- O. A. Gerasimova,
- A. I. Dolgushina,
- M. S. Zhuravleva,
- L. Yu. Ilchenko,
- V. E. Karev,
- N. V. Korochanskaya,
- I. L. Kliaritskaia,
- N. S. Karnaukhov,
- S. V. Lapin,
- M. A. Livzan,
- M. V. Maevskaya,
- N. V. Marchenko,
- T. P. Nekrasova,
- I. G. Nikitin,
- A. A. Novikov,
- R. G. Saifutdinov,
- E. V. Skazyvaeva,
- V. E. Syutkin,
- M. K. Prashnova,
- T. Yu. Khaymenova,
- S. G. Khomerik
Affiliations
- Yu. G. Sandler
- Loginov Moscow Clinical Scientific Center
- E. V. Vinnitskaya
- Loginov Moscow Clinical Scientific Center
- K. L. Raikhelson
- Saint Petersburg State University
- K. V. Ivashkin
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- S. N. Batskikh
- Loginov Moscow Clinical Scientific Center
- E. N. Aleksandrova
- Loginov Moscow Clinical Scientific Center
- D. T. Abdurakhmanov
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- D. I. Abdulganieva
- Kazan State Medical University
- I. G. Bakulin
- North-Western State Medical University named after I.I. Mechnikov
- A. O. Bueverov
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- S. L. Vorobyev
- OOO National Center for Clinical Morphological Diagnostics
- O. A. Gerasimova
- Saint Petersburg State University; Russian Scientific Center for Radiology and Surgical Technologies named after Academician A.M. Granov
- A. I. Dolgushina
- South Ural State Medical University
- M. S. Zhuravleva
- North-Western State Medical University named after I.I. Mechnikov
- L. Yu. Ilchenko
- N.I. Pirogov Russian National Research Medical University
- V. E. Karev
- Pediatric Research and Clinical Center for Infectious Diseases under the Federal Medical Biological Agency
- N. V. Korochanskaya
- Kuban State Medical University
- I. L. Kliaritskaia
- V.I. Vernadsky Crimean Federal University
- N. S. Karnaukhov
- Loginov Moscow Clinical Scientific Center
- S. V. Lapin
- Academician I.P. Pavlov First St. Petersburg State Medical University
- M. A. Livzan
- Omsk State Medical University
- M. V. Maevskaya
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- N. V. Marchenko
- Russian Scientific Center for Radiology and Surgical Technologies named after Academician A.M. Granov
- T. P. Nekrasova
- I.M. Sechenov First Moscow State Medical University (Sechenov University)
- I. G. Nikitin
- N.I. Pirogov Russian National Research Medical University
- A. A. Novikov
- Loginov Moscow Clinical Scientific Center
- R. G. Saifutdinov
- Kazan State Medical Academy — Branch Campus of the Russian Medical Academy of Continuous Professional Education
- E. V. Skazyvaeva
- North-Western State Medical University named after I.I. Mechnikov
- V. E. Syutkin
- Medical and Biological University of Innovation and Continuous Education, State Research Center — Byrnasyan Federal Medical Biophysical Center of Federal Biological Agency; N.V. Sklifosovsky Research Institute for Emergency Care of the Moscow City Health Department
- M. K. Prashnova
- Russian Scientific Center for Radiology and Surgical Technologies named after Academician A.M. Granov
- T. Yu. Khaymenova
- Loginov Moscow Clinical Scientific Center
- S. G. Khomerik
- Loginov Moscow Clinical Scientific Center
- DOI
- https://doi.org/10.22416/1382-4376-2024-34-6-100-119
- Journal volume & issue
-
Vol. 34,
no. 6
pp. 100 – 119
Abstract
Background. In the last decade, the understanding of the pathogenesis of autoimmune hepatitis (AIH) has significantly deepened, based on the results of new clinical studies some diagnostic issues have been revised and immunosuppressive therapy regimens have been optimized.Materials and methods. The latest Russian clinical guidelines for the diagnosis and treatment of AIH were presented in 2013; and in 2017, the first Russian agreement on the diagnosis and treatment of AIH was held. Updating approaches to the management of patients with AIH necessitated next systematization for use in clinical practice. In February 2024, the final session was held to discuss the provisions of the second agreement on the diagnosis and treatment of AIH.Results. This publication presents the main discussion points of the agreement regarding methods and algorithms for detecting autoantibodies, the role of liver biopsy, revised morphological criteria for AIH, optimized immunosuppressive therapy regimens, updated criteria for assessing the response to therapy.Conclusions. The agreement was the result of the work of a group of experts on the diagnosis and treatment of AIH and represents the basis for the creation of updated federal clinical guidelines.
Keywords
