Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells

Chaoting Yan; Chaoting Yan; Chaoting Yan; Jinhua Yu; Jinhua Yu

doi:10.3389/fdmed.2021.806001

Frontiers in Dental Medicine (Mar 2022)

Noncoding RNA in Extracellular Vesicles Regulate Differentiation of Mesenchymal Stem Cells

Chaoting Yan,
Chaoting Yan,
Chaoting Yan,
Jinhua Yu,
Jinhua Yu

Affiliations

Chaoting Yan: Key Laboratory of Oral Diseases of Jiangsu Province and Stomatological Institute of Nanjing Medical University, Nanjing, China
Chaoting Yan: Endodontic Department, School of Stomatology, Nanjing Medical University, Nanjing, China
Chaoting Yan: Department of Stomatology, The First People's Hospital of Lianyungang, Lianyungang Clinical Medical College of Nanjing Medical University, Lianyungang, China
Jinhua Yu: Key Laboratory of Oral Diseases of Jiangsu Province and Stomatological Institute of Nanjing Medical University, Nanjing, China
Jinhua Yu: Endodontic Department, School of Stomatology, Nanjing Medical University, Nanjing, China

DOI: https://doi.org/10.3389/fdmed.2021.806001
Journal volume & issue: Vol. 2

Abstract

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To achieve the desired outcome in tissue engineering regeneration, mesenchymal stem cells need to undergo a series of biological processes, including differentiating into the ideal target cells. The extracellular vesicle (EV) in the microenvironment contributes toward determining the fate of the cells with epigenetic regulation, particularly from noncoding RNA (ncRNA), and exerts transportation and protective effects on ncRNAs. We focused on the components and functions of ncRNA (particularly microRNA) in the EVs. The EVs modified by the ncRNA favor tissue regeneration and pose a potential challenge.

Published in Frontiers in Dental Medicine

ISSN: 2673-4915 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Dentistry
Website: https://www.frontiersin.org/journals/dental-medicine#

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