Frontiers in Aging Neuroscience (Sep 2022)

Pharmacotherapeutic potential of pomegranate in age-related neurological disorders

  • Mohammad Javad Emami Kazemabad,
  • Sara Asgari Toni,
  • Neda Tizro,
  • Parisa Alsadat Dadkhah,
  • Hanieh Amani,
  • Shima Akhavan Rezayat,
  • Zahra Sheikh,
  • Mohammad Mohammadi,
  • Dorsa Alijanzadeh,
  • Farnoosh Alimohammadi,
  • Mehregan Shahrokhi,
  • Gisou Erabi,
  • Masoud Noroozi,
  • Mohammad Amin Karimi,
  • Sara Honari,
  • Niloofar Deravi

DOI
https://doi.org/10.3389/fnagi.2022.955735
Journal volume & issue
Vol. 14

Abstract

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Age-related neurological disorders [AND] include neurodegenerative diseases [NDDs] such as Alzheimer's disease [AD] and Parkinson's disease [PD], which are the most prevalent types of dementia in the elderly. It also includes other illnesses such as migraine and epilepsy. ANDs are multifactorial, but aging is their major risk factor. The most frequent and vital pathological features of AND are oxidative stress, inflammation, and accumulation of misfolded proteins. As AND brain damage is a significant public health burden and its incidence is increasing, much has been done to overcome it. Pomegranate (Punica granatum L.) is one of the polyphenol-rich fruits that is widely mentioned in medical folklore. Pomegranate is commonly used to treat common disorders such as diarrhea, abdominal pain, wound healing, bleeding, dysentery, acidosis, microbial infections, infectious and noninfectious respiratory diseases, and neurological disorders. In the current review article, we aimed to summarize the data on the pharmacotherapeutic potentials of pomegranate in ANDs.

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