Nature Communications (Jun 2020)
Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines
- Silvia Argimón,
- Melissa A. L. Masim,
- June M. Gayeta,
- Marietta L. Lagrada,
- Polle K. V. Macaranas,
- Victoria Cohen,
- Marilyn T. Limas,
- Holly O. Espiritu,
- Janziel C. Palarca,
- Jeremiah Chilam,
- Manuel C. Jamoralin,
- Alfred S. Villamin,
- Janice B. Borlasa,
- Agnettah M. Olorosa,
- Lara F. T. Hernandez,
- Karis D. Boehme,
- Benjamin Jeffrey,
- Khalil Abudahab,
- Charmian M. Hufano,
- Sonia B. Sia,
- John Stelling,
- Matthew T. G. Holden,
- David M. Aanensen,
- Celia C. Carlos
Affiliations
- Silvia Argimón
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus
- Melissa A. L. Masim
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- June M. Gayeta
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Marietta L. Lagrada
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Polle K. V. Macaranas
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Victoria Cohen
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus
- Marilyn T. Limas
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Holly O. Espiritu
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Janziel C. Palarca
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Jeremiah Chilam
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Manuel C. Jamoralin
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Alfred S. Villamin
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Janice B. Borlasa
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Agnettah M. Olorosa
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Lara F. T. Hernandez
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Karis D. Boehme
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Benjamin Jeffrey
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus
- Khalil Abudahab
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus
- Charmian M. Hufano
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- Sonia B. Sia
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- John Stelling
- Brigham and Women’s Hospital
- Matthew T. G. Holden
- University of St Andrews School of Medicine
- David M. Aanensen
- Centre for Genomic Pathogen Surveillance, Wellcome Genome Campus
- Celia C. Carlos
- Antimicrobial Resistance Surveillance Reference Laboratory, Research Institute for Tropical Medicine
- DOI
- https://doi.org/10.1038/s41467-020-16322-5
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
Whole-genome sequencing (WGS) can support drug resistance surveillance, but is rare in low- and middle-income countries. Here, the authors integrate WGS within the national antimicrobial resistance surveillance program in the Philippines and conduct a retrospective sequencing survey to characterize bacterial populations and dissect resistance phenotypes.
