PLoS ONE (Jan 2013)

Survival of patients with hepatocellular carcinoma (HCC) treated by percutaneous radio-frequency ablation (RFA) is affected by complete radiological response.

  • Giuseppe Cabibbo,
  • Giuseppe Cabibbo,
  • Marcello Maida,
  • Chiara Genco,
  • Nicola Alessi,
  • Marco Peralta,
  • Giuseppe Butera,
  • Massimo Galia,
  • Giuseppe Brancatelli,
  • Claudio Genova,
  • Maurizio Raineri,
  • Emanuele Orlando,
  • Simona Attardo,
  • Antonino Giarratano,
  • Massimo Midiri,
  • Vito Di Marco,
  • Antonio Craxì,
  • Calogero Cammà

DOI
https://doi.org/10.1371/journal.pone.0070016
Journal volume & issue
Vol. 8, no. 7
p. e70016

Abstract

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BACKGROUND: Radio-frequency ablation (RFA) has been employed in the treatment of Barcelona Clinic Liver Cancer (BCLC) early stage hepatocellular carcinoma (HCC) as curative treatments. AIM: To assess the effectiveness and the safety of RFA in patients with early HCC and compensated cirrhosis. METHODS: A cohort of 151 consecutive patients with early stage HCC (122 Child-Pugh class A and 29 class B patients) treated with RFA were enrolled. Clinical, laboratory and radiological follow-up data were collected from the time of first RFA. A single lesion was observed in 113/151 (74.8%), two lesions in 32/151 (21.2%), and three lesions in 6/151 (4%) of patients. RESULTS: The overall survival rates were 94%, 80%, 64%, 49%, and 41% at 12, 24, 36, 48 and 60 months, respectively. Complete response (CR) at 1 month (p<0.0001) and serum albumin levels (p = 0.0004) were the only variables indipendently linked to survival by multivariate Cox model. By multivariate analysis, tumor size (p = 0.01) is the only variable associated with an increased likehood of CR. The proportion of major complications after treatment was 4%. CONCLUSIONS: RFA is safe and effective for managing HCC with cirrhosis, especially for patients with HCC ≤3 cm and higher baseline albumin levels. Complete response after RFA significantly increases survival.