Communications Biology (Jul 2021)
ChAdOx1 nCoV-19 protection against SARS-CoV-2 in rhesus macaque and ferret challenge models
- Teresa Lambe,
- Alexandra J. Spencer,
- Kelly M. Thomas,
- Karen E. Gooch,
- Stephen Thomas,
- Andrew D. White,
- Holly E. Humphries,
- Daniel Wright,
- Sandra Belij-Rammerstorfer,
- Nazia Thakur,
- Carina Conceicao,
- Robert Watson,
- Leonie Alden,
- Lauren Allen,
- Marilyn Aram,
- Kevin R. Bewley,
- Emily Brunt,
- Phillip Brown,
- Breeze E. Cavell,
- Rebecca Cobb,
- Susan A. Fotheringham,
- Ciaran Gilbride,
- Debbie J. Harris,
- Catherine M. K. Ho,
- Laura Hunter,
- Chelsea L. Kennard,
- Stephanie Leung,
- Vanessa Lucas,
- Didier Ngabo,
- Kathryn A. Ryan,
- Hannah Sharpe,
- Charlotte Sarfas,
- Laura Sibley,
- Gillian S. Slack,
- Marta Ulaszewska,
- Nadina Wand,
- Nathan R. Wiblin,
- Fergus V. Gleeson,
- Dalan Bailey,
- Sally Sharpe,
- Sue Charlton,
- Francisco J. Salguero,
- Miles W. Carroll,
- Sarah C. Gilbert
Affiliations
- Teresa Lambe
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Alexandra J. Spencer
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Kelly M. Thomas
- National Infection Service, Public Health England
- Karen E. Gooch
- National Infection Service, Public Health England
- Stephen Thomas
- National Infection Service, Public Health England
- Andrew D. White
- National Infection Service, Public Health England
- Holly E. Humphries
- National Infection Service, Public Health England
- Daniel Wright
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Sandra Belij-Rammerstorfer
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Nazia Thakur
- The Pirbright Institute, Woking
- Carina Conceicao
- The Pirbright Institute, Woking
- Robert Watson
- National Infection Service, Public Health England
- Leonie Alden
- National Infection Service, Public Health England
- Lauren Allen
- National Infection Service, Public Health England
- Marilyn Aram
- National Infection Service, Public Health England
- Kevin R. Bewley
- National Infection Service, Public Health England
- Emily Brunt
- National Infection Service, Public Health England
- Phillip Brown
- National Infection Service, Public Health England
- Breeze E. Cavell
- National Infection Service, Public Health England
- Rebecca Cobb
- National Infection Service, Public Health England
- Susan A. Fotheringham
- National Infection Service, Public Health England
- Ciaran Gilbride
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Debbie J. Harris
- National Infection Service, Public Health England
- Catherine M. K. Ho
- National Infection Service, Public Health England
- Laura Hunter
- National Infection Service, Public Health England
- Chelsea L. Kennard
- National Infection Service, Public Health England
- Stephanie Leung
- National Infection Service, Public Health England
- Vanessa Lucas
- National Infection Service, Public Health England
- Didier Ngabo
- National Infection Service, Public Health England
- Kathryn A. Ryan
- National Infection Service, Public Health England
- Hannah Sharpe
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Charlotte Sarfas
- National Infection Service, Public Health England
- Laura Sibley
- National Infection Service, Public Health England
- Gillian S. Slack
- National Infection Service, Public Health England
- Marta Ulaszewska
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- Nadina Wand
- National Infection Service, Public Health England
- Nathan R. Wiblin
- National Infection Service, Public Health England
- Fergus V. Gleeson
- Department of Oncology, University of Oxford
- Dalan Bailey
- The Pirbright Institute, Woking
- Sally Sharpe
- National Infection Service, Public Health England
- Sue Charlton
- National Infection Service, Public Health England
- Francisco J. Salguero
- National Infection Service, Public Health England
- Miles W. Carroll
- National Infection Service, Public Health England
- Sarah C. Gilbert
- The Jenner Institute, Nuffield Department of Medicine, University of Oxford
- DOI
- https://doi.org/10.1038/s42003-021-02443-0
- Journal volume & issue
-
Vol. 4,
no. 1
pp. 1 – 12
Abstract
Lambe, Spencer, Thomas, Gilbert and colleagues report on the detailed immune profile of rhesus macaques and ferrets vaccinated against SARS-CoV-2 under high dose challenge. Their findings indicate that the ChAdOx1 nCoV-19 (AZD1222) the vaccine induces immune responses and reduces disease symptoms in both models, including SARS-CoV-2 mediated pneumonia and virus shedding.
