A reference haplotype panel for genome-wide imputation of short tandem repeats

Shubham Saini; Ileena Mitra; Nima Mousavi; Stephanie Feupe Fotsing; Melissa Gymrek

doi:10.1038/s41467-018-06694-0

Nature Communications (Oct 2018)

A reference haplotype panel for genome-wide imputation of short tandem repeats

Shubham Saini,
Ileena Mitra,
Nima Mousavi,
Stephanie Feupe Fotsing,
Melissa Gymrek

Affiliations

Shubham Saini: Department of Computer Science and Engineering, University of California San Diego
Ileena Mitra: Bioinformatics and Systems Biology Program, University of California San Diego
Nima Mousavi: Department of Electrical and Computer Engineering, University of California, San Diego
Stephanie Feupe Fotsing: Bioinformatics and Systems Biology Program, University of California San Diego
Melissa Gymrek: Department of Computer Science and Engineering, University of California San Diego

DOI: https://doi.org/10.1038/s41467-018-06694-0
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 11

Abstract

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Short-tandem repeats (STR), similar to single nucleotide polymorphisms (SNP), contribute to complex traits, but their ascertainment by next-generation sequencing is costly. Here, Saini et al. provide a SNP+STR haplotype reference panel that allows imputation of STRs from SNP array data.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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