Schlenk line protocols for using SmI2 and the impact of THF solvent

Abstract

Samarium diiodide (SmI2) is a single electron reductant and versatile synthetic tool that can be used to create carbon- carbon bonds or other synthetic transformations. SmI2 is typically used with an Argon atmosphere glovebox and anhydrous solvents from a solvent purification system; however, not all labs have access to these equipment. A more accessible air-free option is Schlenk line glassware. Here in reports an optimized method for the synthesis and use of SmI2 on a Schlenk line. During optimization of the system, it was found that the largest impact on the success of SmI2 was the THF solvent. Anhydrous solvent was achieved though distillation, but after storage of the solvent over two weeks enough moisture/air was accumulated to significantly impact the concentration of the SmI2 formed in solution. The use of molecular sieves further indicates that the impact of water accumulation in the solvent compared to oxygen has the most significant factor on the success of synthesizing SmI2. These observations of THF storage overtime are important to account for when carrying out SmI2 reactions and other air-sensitive reactions on the Schlenk line.

Keywords

• SmI2 synthesis
• Air-free reactions
• Method development