The Effect of Thermal Pain on Cisplatin Sensitivity of Rats Issues Hydration

Abstract

Although cisplatin is a highly effective anticancer agent, it has been noted to have severe side effects including renal toxicity, gastrointestinal toxicity, nephrotoxicity, ototoxicity, and optic neuropathy leading to the limits of its use in the clinic. The primary target for cisPt effect is considered the genomic DNA; however, multiple cellular targets by cisPt have been described. Therefore, the evaluation of methods for anticancer effects and the decrease of side effects of cisPt is the key problem of modern clinical challenges. For the purposes to find out cell target parameters, through which the dose-dependent effects of cisPt can be studied to discover low-doses of it having effective therapeutic and fewer side effects. The vagueness of the nature of the membrane target mechanism through which the antitumor effect of cisPt is realized makes it the main barrier for finding out the minimum dose needed for clinical efficacy and toxic dose challenges for clinical practice. Therefore, the purpose of the present work is as follows: to check cisPt sensitivity tissues hydration of different organs and thermal pain effect on cisPt-induced tissues hydration of different organs. The obtained data allow us to conclude that the thermal pain enhances the dehydration effect of 10-10M cisPt which in turn prolongs the longevity of cells and low concentration of cisPt activates the metabolism of tissues of young rats.

Keywords

• cisplatin
• thermal pain