Reconstituting the complete biosynthesis of D-lysergic acid in yeast

Garrett Wong; Li Rong Lim; Yong Quan Tan; Maybelle Kho Go; David J. Bell; Paul S. Freemont; Wen Shan Yew

doi:10.1038/s41467-022-28386-6

Nature Communications (Feb 2022)

Reconstituting the complete biosynthesis of D-lysergic acid in yeast

Garrett Wong,
Li Rong Lim,
Yong Quan Tan,
Maybelle Kho Go,
David J. Bell,
Paul S. Freemont,
Wen Shan Yew

Affiliations

Garrett Wong: Synthetic Biology for Clinical and Technological Innovation, National University of Singapore
Li Rong Lim: Synthetic Biology for Clinical and Technological Innovation, National University of Singapore
Yong Quan Tan: Synthetic Biology for Clinical and Technological Innovation, National University of Singapore
Maybelle Kho Go: Synthetic Biology for Clinical and Technological Innovation, National University of Singapore
David J. Bell: Department of Infectious Diseases, Faculty of Medicine, Imperial College London
Paul S. Freemont: Department of Infectious Diseases, Faculty of Medicine, Imperial College London
Wen Shan Yew: Synthetic Biology for Clinical and Technological Innovation, National University of Singapore

DOI: https://doi.org/10.1038/s41467-022-28386-6
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 10

Abstract

Read online

The ergot alkaloids are a class of natural products known for their pharmacologically privileged molecular structure that are used in the treatment of neurological ailments. Here the authors report on the production of the ergot (fungus)-derived therapeutic precursor, D-lysergic acid (DLA), in baker’s yeast.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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