Oral leukoplakia in adolescents: Attention to differential diagnosis of inherited genetic syndromes with emphasis on dyskeratosis congenita and Fanconi anemia

Shiyi Chen; Chenbin Xu; Yizhen Wu; Wei Liu; Xi Yang

Oral Oncology Reports (Jun 2023)

Oral leukoplakia in adolescents: Attention to differential diagnosis of inherited genetic syndromes with emphasis on dyskeratosis congenita and Fanconi anemia

Shiyi Chen,
Chenbin Xu,
Yizhen Wu,
Wei Liu,
Xi Yang

Affiliations

Shiyi Chen: College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China
Chenbin Xu: College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China
Yizhen Wu: College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China
Wei Liu: College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China; Department of Oral Mucosal Diseases, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding author. College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, 200011, China.
Xi Yang: College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China; Department of Oral and Maxillofacial-Head and Neck Oncology, Shanghai Center of Head and Neck Oncology Clinical and Translational Science, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Corresponding author. College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.

Journal volume & issue: Vol. 6
p. 100043

Abstract

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Among inherited cancer syndromes, dyskeratosis congenita (DKC) and Fanconi anemia (FA) are most closely associated with the onset and progression of oral potentially malignant disorders (OPMD) with emphasis on oral leukoplakia (OLK) in adolescents. DKC often arises early and should always be considered and excluded in a child presenting with OLK. A total of 30 (41.1%) of 73 FA patients compatible with OPMD further developed into oral cancer at the young age (10–30 years old) are identified in literature. Individuals with inherited genetic syndromes, especially DKC and FA, should be a target young population with increased risk of OPMD onset and further progression to oral cancer. Hence, it is suggested that OLK in adolescents should pay attention to differential diagnosis of inherited genetic syndromes, mainly DKC and FA.

Published in Oral Oncology Reports

ISSN: 2772-9060 (Online)
Publisher: Elsevier
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://www.sciencedirect.com/journal/oral-oncology-reports

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