Química Nova (Jan 2007)

Desviaciones al modelo logarítmico-lineal en la solubilidad de ibuprofén y naproxén en mezclas cosolventes propilenoglicol-agua Deviations from log-linear solubility equation for ibuprofen and naproxen in propylene glycol-water cosolvent mixtures

  • Edgar F. Vargas,
  • Yady J. Manrique,
  • Diana P. Pacheco,
  • Norma S. Torres,
  • Fleming Martínez

DOI
https://doi.org/10.1590/S0100-40422007000800028
Journal volume & issue
Vol. 30, no. 8
pp. 1945 – 1950

Abstract

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The deviations observed in the solubility of ibuprofen (IBP) and naproxen (NAP) in propylene glycol (PG) + water (W) cosolvent mixtures with respect to the logarithmic-linear model proposed by Yalkowsky have been analyzed at 25.00 ± 0.05 ºC. Negative deviations were obtained in all cosolvent compositions for both drugs; they were greater for IBP. Another treatment, based on Gibbs free energy relationships, was also employed showing an apparent hydrophobicity chameleonic effect, because at low PG proportions NAP is more hydrophobic, whereas at high PG proportions IBP is more hydrophobic. The results are discussed in terms of solute-solvent and solvent-solvent interactions.

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