PARAMETERS OF BONE METABOLISM IN PRE-AND POSTMENOPAUSAL WOMEN WITH TYPE 2 DIABETES MELLITUS IN THE RATIONALE FOR THE CHOICE OF ANTIOSTEOPOROTIC THERAPY

Abstract

Introduction. Bone health in type 2 diabetes mellitus (T2DM) is discussed for a long time as a known fact for increased risk of fractures. Purpose. To estimate the parameters of bone remodeling in pre-andpostmenopausal women with T2DM. Materials and Methods. In a cross-sectional pilot study which included 80 women: 40 with T2DM and 40 without disturbances of glucose metabolism (K), divided into subgroups of premenopausal (pre) and natural menopause (post) — 20 patients each. Results and conclusions. We found a tendency toward a decrease in bone turnover in patients T2DM, a significant negative relationship with C-peptide and ALP in T2DM, a positive correlation with tartrate — resistant acid phosphatase in the control group, although the levels of C-peptide did not differ in patients with T2DM and in the control group . Identified characteristics of decreased bone remodeling in patients with T2DM pathogenically justify the use of anabolic antiosteoporotic drugs for treatment of osteoporosis in such patients.

Keywords

• остеопороз
• сахарный диабет 2 типа
• СД 2
• маркеры костного метаболизма