Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

A. Vuorela; T. L. Freitag; K. Leskinen; H. Pessa; T. Härkönen; I. Stracenski; T. Kirjavainen; P. Olsen; O. Saarenpää-Heikkilä; J. Ilonen; M. Knip; A. Vaheri; M. Partinen; P. Saavalainen; S. Meri; O. Vaarala

doi:10.1038/s41467-021-22637-8

Nature Communications (Apr 2021)

Enhanced influenza A H1N1 T cell epitope recognition and cross-reactivity to protein-O-mannosyltransferase 1 in Pandemrix-associated narcolepsy type 1

A. Vuorela,
T. L. Freitag,
K. Leskinen,
H. Pessa,
T. Härkönen,
I. Stracenski,
T. Kirjavainen,
P. Olsen,
O. Saarenpää-Heikkilä,
J. Ilonen,
M. Knip,
A. Vaheri,
M. Partinen,
P. Saavalainen,
S. Meri,
O. Vaarala

Affiliations

A. Vuorela: Clinicum, University of Helsinki
T. L. Freitag: Department of Bacteriology and Immunology, University of Helsinki
K. Leskinen: Translational Immunology Research Program, University of Helsinki
H. Pessa: Translational Immunology Research Program, University of Helsinki
T. Härkönen: Clinicum, University of Helsinki
I. Stracenski: Department of Bacteriology and Immunology, University of Helsinki
T. Kirjavainen: Children’s Hospital, University of Helsinki, and Helsinki University Hospital
P. Olsen: Department of Child Neurology, Oulu University Hospital
O. Saarenpää-Heikkilä: Department of Pediatrics, Tampere University Hospital
J. Ilonen: Immunogenetics Laboratory, Institute of Biomedicine, University of Turku
M. Knip: Clinicum, University of Helsinki
A. Vaheri: Department of Virology, University of Helsinki
M. Partinen: Clinicum, University of Helsinki
P. Saavalainen: Translational Immunology Research Program, University of Helsinki
S. Meri: Department of Bacteriology and Immunology, University of Helsinki
O. Vaarala: Clinicum, University of Helsinki

DOI: https://doi.org/10.1038/s41467-021-22637-8
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 17

Abstract

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Narcolepsy type 1 (NT1) is a severe sleep disorder with strong association to the HLA type DQB1*0602 and increased incidence among children vaccinated with the Influenza A vaccine Pandemrix. Here the authors show that these children develop T and B cell autoimmunity against protein-O-mannosyltransferase 1 via cross-reactivity.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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