Adipose-Derived Stem Cell Exosomes Facilitate Diabetic Wound Healing: Mechanisms and Potential Applications

Abstract

Kang Wang,1,* Zihui Yang,1,* Boyu Zhang,1,* Song Gong,2 Yiping Wu1 1Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China; 2Division of Endocrinology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Song Gong, Division of Endocrinology, Tongji Hospital, Tongji Medical College, Wuhan, Hubei, People’s Republic of China, Email [email protected] Yiping Wu, Department of Plastic and Cosmetic Surgery, Tongji Hospital, Tongji Medical College, Wuhan, Hubei, People’s Republic of China, Email [email protected]: Wound healing in diabetic patients is frequently hampered. Adipose-derived stem cell exosomes (ADSC-eoxs), serving as a crucial mode of intercellular communication, exhibit promising therapeutic roles in facilitating wound healing. This review aims to comprehensively outline the molecular mechanisms through which ADSC-eoxs enhance diabetic wound healing. We emphasize the biologically active molecules released by these exosomes and their involvement in signaling pathways associated with inflammation modulation, cellular proliferation, vascular neogenesis, and other pertinent processes. Additionally, the clinical application prospects of the reported ADSC-eoxs are also deliberated. A thorough understanding of these molecular mechanisms and potential applications is anticipated to furnish a theoretical groundwork for combating diabetic wound healing.Keywords: diabetes, wound healing, ADSC-exos, tissue regeneration, skin cells, inflammation

Keywords

• diabetes
• wound healing
• adsc-exos
• tissue regeneration
• skin cells
• inflammation