The role of steroid hormones and chemical carcinogen benzo(a)pyrene in premature rupture of membranes in preterm pregnancy

Abstract

The aim of this study was to investigate the levels of estradiol, progesterone; antibodies Ig classes A and G to them and to benzo(a)pyrene in women with premature rupture of membranes (PROM) at 22-36.6 weeks of gestation and in women without PROM in the same period. A retrospective, comparative, analytical study was taken. The study included 149 patients, group 1 consisted of women with PROM at 22-36.6 weeks of gestation (n=68), group 2 - women with a normal pregnancy without PROM at 22-36.6 weeks of gestation (n=81). Isotype differences in the formation of antibodies (Ig) to estradiol were revealed in women from group I compared with group II. High level of IgA antibodies to estradiol is more common in women with PROM at 22-36.6 weeks of gestation.

Keywords

• premature rupture of membranes
• preterm labour
• antibodies
• benzo(a)pyrene
• estradiol
• progesterone