Nature Communications (Aug 2022)

Homotypic and heterotypic immune responses to Omicron variant in immunocompromised patients in diverse clinical settings

  • Victor H. Ferreira,
  • Javier T. Solera,
  • Queenie Hu,
  • Victoria G. Hall,
  • Berta G. Arbol,
  • W. Rod Hardy,
  • Reuben Samson,
  • Tina Marinelli,
  • Matthew Ierullo,
  • Avneet Kaur Virk,
  • Alexandra Kurtesi,
  • Faranak Mavandadnejad,
  • Beata Majchrzak-Kita,
  • Vathany Kulasingam,
  • Anne-Claude Gingras,
  • Deepali Kumar,
  • Atul Humar

DOI
https://doi.org/10.1038/s41467-022-32235-x
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 12

Abstract

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Immunocompromised individuals are predisposed to severe SARS-CoV-2 infection, with transplant recipients typically displaying impaired immune response to pathogens, due to typical life-long immunosuppressive treatment. In this work, the authors evaluate the immune response to Omicron subvariants BA.1 and BA.2 in organ transplant recipients across a diverse clinical spectrum.