Intratumoral co-injection of the poly I:C-derivative BO-112 and a STING agonist synergize to achieve local and distant anti-tumor efficacy

• Pedro Berraondo,
• Ignacio Melero,
• Alvaro Teijeira,
• Carmen Molina,
• Marisol Quintero,
• Fernando Aranda,
• Maite Alvarez,
• Maria E Rodriguez-Ruiz,
• Xinyi Fan,
• Miguel F Sanmamed,
• Javier Glez-Vaz,
• Maria Villalba,
• Carlos E De Andrea,
• Myriam Fernandez-Sendin,
• Jose Gonzalez-Gomariz,
• Maria Carmen Ochoa,
• Wen H Shen

Affiliations

Pedro Berraondo

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Ignacio Melero

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Alvaro Teijeira

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Carmen Molina

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Marisol Quintero

Oncology, Highlight Therapeutics, Valencia, Spain

Fernando Aranda

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Maite Alvarez

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Maria E Rodriguez-Ruiz

Immunology and Oncology, Clinica Universidad de Navarra, Pamplona, Spain

Xinyi Fan

Radiation Oncology, Weill Cornell Medicine, New York, New York, USA

Miguel F Sanmamed

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Javier Glez-Vaz

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Maria Villalba

Centro de Investigacion Biomedica en Red de Cancer (CIBERONC), Madrid, Spain

Carlos E De Andrea

Navarra Institute for Health Research (IdiSNA), Pamplona, Spain

Myriam Fernandez-Sendin

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Jose Gonzalez-Gomariz

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Maria Carmen Ochoa

Immunology and Immunotherapy, Center for Applied Medical Research (CIMA). University of Navarra, Pamplona, Spain

Wen H Shen

Radiation Oncology, Weill Cornell Medicine, New York, New York, USA