Hematology, Transfusion and Cell Therapy (Apr 2024)

177LU-PSMA IN METASTATIC CASTRATION RESISTANT PROSTATE CANCER: PRELIMINARY ANALYSIS OF A BRAZILIAN MULTICENTRIC STUDY

  • Victor Cabral Costa Ribeiro Heringer,
  • Felipe P.G. Ribeiro,
  • Diogo Bastos,
  • Camila Mosci,
  • Dalton A. Anjos,
  • Paulo Almeida Filho,
  • Gustavo Gomes,
  • Filipe Villela-Pedras,
  • Fabio Ribeiro,
  • Julio Correia,
  • José F. Marin,
  • Carlos Buchpiguel,
  • Elba C.S.C. Etchebehere

Journal volume & issue
Vol. 46
p. S14

Abstract

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Introduction/Justification: 177Lu-PSMA can be a promissor therapy in patients with metastatic castration resistant prostate cancer. Objectives: Investigate 177Lu-PSMA therapy in Brazilian patients with metastatic castration resistant prostate cancer (mCRPC). Materials and Methods: Data for this retrospective multicentric study was collected from 9 Brazilian centers from 6 federative units (SP, PE, CE, RJ, SC and DF) that performed at least two cycles of 177Lu-PSMA therapy in mCRPC. Data with skewed distribution were reported as median (min-max). Primary outcome was overall survival. Secondary outcomes was the maximal PSA response and hematological adverse events (HAE). Results: A total of 100 males were included, median age = 74 years old (min-max: 54 - 96 years old). 177Lu-PSMA was the fifth (median) line of therapy (min-max 2-10). A total of 333 cycles were performed with a median of 4 cycles (min-max 1-10). The mean overall survival was 12.8 months. Among the 72 patients with data available for the maximal PSA response at any time, 65% presented any PSA decline. 42% presented PSA decline ≥ 50% from baseline. 89% of patients did not present HAE or presented grades 1 or 2 HAE. Only 11% of patients presented grade 3 HAE. 0% of patients presented grade 4 HAE. Conclusion: 177Lu-PSMA therapy was effective and safe in the Brazilian population even with a median of 5th line of therapy (maximum 10th line). Overall survival and PSA decline ≥ 50% from baseline were similar to the literature data. Only 11% of patients presented grades 3 or 4 hematological adverse events.

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