Nature Communications (Apr 2016)
mTORC1 regulates PTHrP to coordinate chondrocyte growth, proliferation and differentiation
- Bo Yan,
- Zhongmin Zhang,
- Dadi Jin,
- Chen Cai,
- Chunhong Jia,
- Wen Liu,
- Ting Wang,
- Shengfa Li,
- Haiyan Zhang,
- Bin Huang,
- Pinglin Lai,
- Hua Wang,
- Anling Liu,
- Chun Zeng,
- Daozhang Cai,
- Yu Jiang,
- Xiaochun Bai
Affiliations
- Bo Yan
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- Zhongmin Zhang
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- Dadi Jin
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- Chen Cai
- Department of Orthopedics, Zhujiang Hospital, Southern Medical University
- Chunhong Jia
- Department of Cell Biology, State Key Laboratory of Organ Failure Research, School of Basic Medical Sciences, Southern Medical University
- Wen Liu
- Department of Cell Biology, State Key Laboratory of Organ Failure Research, School of Basic Medical Sciences, Southern Medical University
- Ting Wang
- Department of Cell Biology, State Key Laboratory of Organ Failure Research, School of Basic Medical Sciences, Southern Medical University
- Shengfa Li
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- Haiyan Zhang
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- Bin Huang
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- Pinglin Lai
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- Hua Wang
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- Anling Liu
- Department of Cell Biology, State Key Laboratory of Organ Failure Research, School of Basic Medical Sciences, Southern Medical University
- Chun Zeng
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- Daozhang Cai
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- Yu Jiang
- Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine
- Xiaochun Bai
- Academy of Orthopedics, Guangdong Province, The Third Affiliated Hospital, Southern Medical University
- DOI
- https://doi.org/10.1038/ncomms11151
- Journal volume & issue
-
Vol. 7,
no. 1
pp. 1 – 15
Abstract
mTORC1 is crucial for chondrocyte proliferation and bone growth, but the downstream signalling is not clear. Here, the authors use rapamycin and chondrocyte-specific Tsc1 knockout mice to show that S6K1 can cause nuclear accumulation of Gli2, thus driving PTHrP expression and preventing terminal differentiation of prehypertrophic chondrocytes.
