Angiocrine extracellular vesicles impose mesenchymal reprogramming upon proneural glioma stem cells

Abstract

Glioma stem-like cells (GSCs) exhibit plasticity during proneural-to-mesenchymal transition. Here the authors show that extracellular vesicles from endothelial cells can promote this transition of GSCs through activation of MMPs and NFkB, and inactivation of NOTCH.