Cord Blood Spexin Level in Mothers with Obesity—Forecast of Future Obesity?
Malgorzata Wojciechowska,
Pawel A. Kolodziejski,
Ewa Pruszynska-Oszmalek,
Natalia Leciejewska,
Hanna Krauss,
Zuzanna Checinska-Maciejewska,
Maciej Sassek,
Anna Rekas-Dudziak,
Malgorzata Bernatek,
Marek Skrzypski,
Maciej Wilczak
Affiliations
Malgorzata Wojciechowska
Department of Mother and Child Health, Poznan University of Medical Sciences, 61-806 Poznan, Poland
Pawel A. Kolodziejski
Department of Animal Physiology, Biochemistry and Biostructure, Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Wolynska Street 35, 60-637 Poznan, Poland
Ewa Pruszynska-Oszmalek
Department of Animal Physiology, Biochemistry and Biostructure, Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Wolynska Street 35, 60-637 Poznan, Poland
Natalia Leciejewska
Department of Animal Physiology, Biochemistry and Biostructure, Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Wolynska Street 35, 60-637 Poznan, Poland
Hanna Krauss
Department of Medicine, The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz, 62-800 Kalisz, Poland
Zuzanna Checinska-Maciejewska
Department of Medicine, The President Stanisław Wojciechowski State University of Applied Sciences in Kalisz, 62-800 Kalisz, Poland
Maciej Sassek
Department of Mother and Child Health, Poznan University of Medical Sciences, 61-806 Poznan, Poland
Anna Rekas-Dudziak
Department of Anaesthesiology and Intensive Care, Hospital of the Ministry of the Internal Affairs and Administration, 60-631 Poznan, Poland
Malgorzata Bernatek
State Hospital Jarocin, Szpitalna 1, 63-200 Jarocin, Poland
Marek Skrzypski
Department of Animal Physiology, Biochemistry and Biostructure, Faculty of Veterinary Medicine and Animal Science, Poznan University of Life Sciences, Wolynska Street 35, 60-637 Poznan, Poland
Maciej Wilczak
Department of Mother and Child Health, Poznan University of Medical Sciences, 61-806 Poznan, Poland
Spexin (SPX) is a peptide that plays an important role in the regulation of food intake and body weight (BW) by the effect on carbohydrate-lipid metabolism. However, the role of SPX in fetal life, in children, and in adolescent metabolism is limited. Therefore, we decided to check whether obesity affects the concentration of SPX in the mother’s peripheral blood (MB) and umbilical cord blood (UCB). Using MB and UCB sera on the day of delivery obtained from 48 women (24 non-obese and 24 obese) and commercially available Elisa kits and colorimetric assays, we determined changes in SPX and the relationship between SPX concentration and other metabolic and anthropometric markers (body weight and BMI) on the day of delivery and in children at the age of 36 months. We found lower concentrations of SPX in MB (p p 30) and a moderate linear correlation (r = 0.4429; p p < 0.05). Based on the obtained results, it can be assumed that spexin is one of the factors modulating the child’s metabolism already in the fetal period and can be considered a potential marker of future predisposition to obesity. However, confirmation of this thesis requires additional research.
