Antihypoxic, anti-ischemic and acute toxicity effect of Salvia leriifolia Benth. root in mice and rats

Abstract

The antihypoxic effect Salvia leriifolia root aqueous and ethanolic extracts was studied using hypoxia creating in a tightly glass container in mice. Ischemia was induced using four-vessel occlusion model and evaluated by optical and transmission electrinic microscope in rats. The extract of S. leriifolia showed antihypoxic effect and the minimum effective dose was 0.7 g/kg. In ischemic rat, the aqueous and ethanolic extracts significantly reduced neural cell injury in CA1 and CA3, 4 hippocampus rats. LD50 values (i.p, mice) of the aqueous and the ethanolic extracts were 1.45 g/kg and 1.55 g/kg, respectively. Both extracts comprised saponins and tannins. These results indincate that the extracts of S. leriifolia root have protective effect against hypoxia and ischemia.

Keywords

• salvia leriifolia
• antihypoxic activity
• anti-ischemic activity
• hippocampus