A predictable conserved DNA base composition signature defines human core DNA replication origins

Ildem Akerman; Bahar Kasaai; Alina Bazarova; Pau Biak Sang; Isabelle Peiffer; Marie Artufel; Romain Derelle; Gabrielle Smith; Marta Rodriguez-Martinez; Manuela Romano; Sandrina Kinet; Peter Tino; Charles Theillet; Naomi Taylor; Benoit Ballester; Marcel Méchali

doi:10.1038/s41467-020-18527-0

Nature Communications (Sep 2020)

A predictable conserved DNA base composition signature defines human core DNA replication origins

Ildem Akerman,
Bahar Kasaai,
Alina Bazarova,
Pau Biak Sang,
Isabelle Peiffer,
Marie Artufel,
Romain Derelle,
Gabrielle Smith,
Marta Rodriguez-Martinez,
Manuela Romano,
Sandrina Kinet,
Peter Tino,
Charles Theillet,
Naomi Taylor,
Benoit Ballester,
Marcel Méchali

Affiliations

Ildem Akerman: Institute of Human Genetics, CNRS - University of Montpellier
Bahar Kasaai: Institute of Human Genetics, CNRS - University of Montpellier
Alina Bazarova: Centre for Computational Biology (CCB), University of Birmingham
Pau Biak Sang: Institute of Human Genetics, CNRS - University of Montpellier
Isabelle Peiffer: Institute of Human Genetics, CNRS - University of Montpellier
Marie Artufel: Aix-Marseille University, INSERM, TAGC, UMR S1090
Romain Derelle: Life and Environmental Sciences (LES), University of Birmingham
Gabrielle Smith: Institute of Metabolism and Systems Research (IMSR), University of Birmingham
Marta Rodriguez-Martinez: Institute of Human Genetics, CNRS - University of Montpellier
Manuela Romano: Institut de Génétique Moléculaire de Montpellier (IGMM), University of Montpellier, CNRS
Sandrina Kinet: Institut de Génétique Moléculaire de Montpellier (IGMM), University of Montpellier, CNRS
Peter Tino: Centre for Computational Biology (CCB), University of Birmingham
Charles Theillet: Institut de Recherche en Cancérologie de Montpellier (IRCM)
Naomi Taylor: Institut de Génétique Moléculaire de Montpellier (IGMM), University of Montpellier, CNRS
Benoit Ballester: Aix-Marseille University, INSERM, TAGC, UMR S1090
Marcel Méchali: Institute of Human Genetics, CNRS - University of Montpellier

DOI: https://doi.org/10.1038/s41467-020-18527-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 15

Abstract

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In metazoan the DNA sequence elements characterizing origin specification are unknown. By generating and analysing 19 SNS-seq datasets from different human cell types, the authors reveal a class and features of Core origins of replication which can be predicted by an algorithm.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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