Total synthesis and antimicrobial evaluation of natural albomycins against clinical pathogens

Abstract

Albomycins are promising drug candidates for the treatment of bacterial infections. Here, the authors describe the total syntheses of albomycins δ 1, δ 2, and ε, and evaluate their antimicrobial activity, identifying albomycin δ 2 as a strong agent against S. pneumoniae and S. aureus infections.