New Meroterpenoid Derivatives from the Pomegranate-Derived Endophytic Fungus <i>Talaromyces purpureogenus</i>
Alaa Anwar,
Mohamed S. Elnaggar,
Ahmed M. Elissawy,
Nehal Ibrahim,
Attila Mándi,
Tibor Kurtán,
Zhen Liu,
Sherweit H. El-Ahmady,
Rainer Kalscheuer
Affiliations
Alaa Anwar
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbassia, Cairo 11566, Egypt
Mohamed S. Elnaggar
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbassia, Cairo 11566, Egypt
Ahmed M. Elissawy
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbassia, Cairo 11566, Egypt
Nehal Ibrahim
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbassia, Cairo 11566, Egypt
Attila Mándi
Department of Organic Chemistry, University of Debrecen, P.O. Box 400, 4002 Debrecen, Hungary
Tibor Kurtán
Department of Organic Chemistry, University of Debrecen, P.O. Box 400, 4002 Debrecen, Hungary
Zhen Liu
Key Laboratory of Study and Discovery of Small Targeted Molecules of Hunan Province, School of Medicine, Hunan Normal University, Changsha 410013, China
Sherweit H. El-Ahmady
Department of Pharmacognosy, Faculty of Pharmacy, Ain-Shams University, Abbassia, Cairo 11566, Egypt
Rainer Kalscheuer
Institute of Pharmaceutical Biology and Biotechnology, Heinrich Heine University, Universitätsstrasse 1, 40225 Düsseldorf, Germany
In this study, we report the isolation of two new meroterpenoids, miniolutelide D (1) and miniolutelide E (13-epi-miniolutelide C) (2), along with two meroterpenoidal analogues (3 and 4) and two phenolic compounds (5 and 6) from the endophytic fungus Talaromyces purpureogenus derived from Punica granatum fruits. Their structures were elucidated using extensive MS, 1D, and 2D NMR spectroscopic analyses as well as by comparing with data in the literature. The absolute configurations of 1 and 2 were determined using TDDFT-ECD calculations. Antimicrobial activity was evaluated. Compound 5 displayed significant activity against methicillin-resistant Staphylococcus aureus strain ATCC 700699 and moderate activity against S. aureus strain ATCC 29213.
