Advances in metal graphitic nanocapsules for biomedicine
Shengkai Li,
Yanxia Yang,
Shen Wang,
Yang Gao,
Zhiling Song,
Long Chen,
Zhuo Chen
Affiliations
Shengkai Li
Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Bio‐Sensing and Chemometrics College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology Hunan University Changsha China
Yanxia Yang
Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Bio‐Sensing and Chemometrics College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology Hunan University Changsha China
Shen Wang
Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Bio‐Sensing and Chemometrics College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology Hunan University Changsha China
Yang Gao
College of Materials Science and Engineering Hunan Province Key Laboratory for Advanced Carbon Materials and Applied Technology Hunan University Changsha China
Zhiling Song
Key Laboratory of Optic‐Electric Sensing and Analytical Chemistry for Life Science MOE Shandong Key Laboratory of Biochemical Analysis College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao China
Long Chen
Faculty of Science and Technology University of Macau Macau SAR China
Zhuo Chen
Molecular Science and Biomedicine Laboratory (MBL) State Key Laboratory of Chemo/Bio‐Sensing and Chemometrics College of Chemistry and Chemical Engineering Aptamer Engineering Center of Hunan Province Hunan Provincial Key Laboratory of Biomacromolecular Chemical Biology Hunan University Changsha China
Abstract Metal graphitic nanocapsules have the advantages of both graphitic and metal nanomaterials, showing great promise in biomedicine. On one hand, the chemically inert graphitic shells are able to protect the metal core from external environments, quench the fluorescence signal from the biological system, offer robust platform for targeted molecules or drugs loading, and act as stable Raman labels or internal standard molecule. On the other hand, the metal cores with different compositions, sizes, and morphologies show unique physicochemical properties, and further broaden their biomedical functions. In this review, we firstly introduce the preparation, classification, and properties of metal graphitic nanocapsules, then summarize the recent progress of their applications in biodetection, bioimaging, and therapy. Challenges and their development prospects in biomedicine are eventually discussed in detail. We expect the versatile metal graphitic nanocapsules will advance the development of future clinical biomedicine.
