INFLAMMASOME NLRP1 DISTINCTIVE FEATURES IN ATOPIC CONDITIONS

Abstract

The review article focuses on the NLRP1 inflammasome, which was discovered before the others but has been the least investigated. The emergence of the inflammasome in innate immunity container cells is an early event that precedes the development of any inflammatory process, including allergic inflammation. The review article describes a structure, major activation signals, NLRP1 activation process, and assotiation with human disease, focusing on atopic conditions, such as atopic dermatitis, allergic rhinitis, and allergic asthma, and provides a rationale for the link of mutations in the NLRP1 sensor gene with genes corresponding to atopy predisposition. The association of NLRP1 with malignant neoplasms is also reported.

Keywords

• атопии
• инфламмасома nlrp1
• пироптоз
• il-1beta
• il-18
• il-33